Piperazine → 2-(4-Fluorophenyl)-7,8-dimethyl-6-piperazin-1-ylimidazo[1,2-b]pyridazine

HRID 80712Notes

Reaction equation

Cl[C:2]1[C:3]([CH3:19])=[C:4]([CH3:18])[C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[N:7]=1.[NH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>O>[F:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[N:10]=[C:5]3[C:4]([CH3:18])=[C:3]([CH3:19])[C:2]([N:20]4[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]4)=[N:7][N:6]3[CH:8]=2)=[CH:12][CH:13]=1

Participants

Conditions

Temperature: 150 °C

Procedure

A mixture of 1.4 g (5.08 mmol) of 6-chloro-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine and 8.7 g (100 mmol) of piperazine is heated at 150° C. for 3 hours in a reactor. The medium is then poured into water and the precipitate formed is isolated by filtration. The product is then recrystallized from a mixture of diisopropyl ether and isopropanol to give 1.15 g of a white powder.

Workup

customthe precipitate formed
customis isolated by filtration
customThe product is then recrystallized from a mixture of diisopropyl ether and isopropanol

Sources & evidence

ORD record: ord-a99e8b74e54943f2bca629a33879f175
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846676B2

Reaction notes

Loading…