1,4-Dioxane → 2-{4-[(4-Tert-butylphenyl)sulfonyl]piperidin-1-yl}-4-(trifluoromethyl)pyridine

HRID 807157Notes

Reaction equation

HRID 807157 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([S:11](=[O:12])(=[O:13])[CH:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[cH:9][cH:10]1.[CH2:40]1[O:41][CH2:42][CH2:43][O:44][CH2:45]1.[CH:31]([N:32]([CH2:33][CH3:34])[CH:35]([CH3:36])[CH3:37])([CH3:38])[CH3:39].[Cl:20][c:21]1[n:22][cH:23][cH:24][c:25]([C:27]([F:28])([F:29])[F:30])[cH:26]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][cH:7][c:8]([S:11](=[O:12])(=[O:13])[CH:14]2[CH2:15][CH2:16][N:17]([c:21]3[n:22][cH:23][cH:24][c:25]([C:27]([F:28])([F:29])[F:30])[cH:26]3)[CH2:18][CH2:19]2)[cH:9][cH:10]1

Participants

5

Reactant 4

HCID 312751,4-DioxaneHCID 81531DiisopropylethylamineHCID 1449582-Chloro-4-(trifluoromethyl)pyridineHCID 185386364-[(4-Tert-butylphenyl)sulfonyl]piperidine

Product 1

HCID 685540522-{4-[(4-Tert-butylphenyl)sulfonyl]piperidin-1-yl}-4-(trifluoromethyl)pyridine

Sources & evidence

ORD record
ord-ee706dddb6954f8eb73fbd16bdf517bc
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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