反应详情

To a solution of 0.43 g (0.86 mmol) of tert-butyl 4-[2-(4-fluorophenyl)-7,8-dimethyl-3-pyrid-4-ylimidazo[1,2-b]pyridazin-6-yl]piperazine-1-carboxylate in 5 mL of dichloromethane at 0° C. is added dropwise 0.64 mL (8.6 mmol) of trifluoroacetic acid. After stirring for 4 hours at room temperature, a further 0.64 mL (8.6 mmol) of trifluoroacetic acid is added and the reaction mixture is left for 18 hours. The solvent is then removed under reduced pressure and the residue is taken up in water. The resulting aqueous phase is washed with ether and then basified by addition of aqueous sodium hydrogen carbonate solution. The product is extracted with dichloromethane, the organic phase is dried over sodium sulfate and filtered, and the solvent is evaporated off to give 0.285 g of a white powder.

1. waitthe reaction mixture is left for 18 hours
2. customThe solvent is then removed under reduced pressure
3. washThe resulting aqueous phase is washed with ether
4. additionbasified by addition of aqueous sodium hydrogen carbonate solution
5. extractionThe product is extracted with dichloromethane
6. dry with materialthe organic phase is dried over sodium sulfate
7. filtrationfiltered
8. customthe solvent is evaporated off