反应详情

48.9 g (278 mmol) of 1-benzylpiperazine and 12.0 g (92.6 mmol) of 3-amino-6-chloropyridazine are heated at 160° C. for 1 hour. The brown oil obtained is poured into 500 mL of aqueous sodium bicarbonate solution and the product is extracted with dichloromethane. The organic phase is dried and then concentrated under reduced pressure. The oil obtained is triturated in diethyl ether, and 20.5 g of a solid are isolated after filtering off and drying.

1. customThe brown oil obtained
2. extractionthe product is extracted with dichloromethane
3. customThe organic phase is dried
4. concentrationconcentrated under reduced pressure
5. customThe oil obtained
6. customis triturated in diethyl ether