Formic Acid → 4-Piperazin-1-yl-6-(tetrahydro-furan-3-yl)-pyrimidin-2-ylamine

HRID 807355Notes

Reaction equation

HRID 807355 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][c:16]([NH2:25])[n:17][c:18]([CH:20]3[CH2:21][O:22][CH2:23][CH2:24]3)[cH:19]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH3:30][OH:31].[CH:27]([OH:28])=[O:29].[ClH:26]>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[n:15][c:16]([NH2:25])[n:17][c:18]([CH:20]3[CH2:21][O:22][CH2:23][CH2:24]3)[cH:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 284Formic AcidHCID 313Hydrochloric AcidHCID 887MethanolHCID 670962764-[2-Amino-6-(tetrahydro-furan-3-yl)-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 532577984-Piperazin-1-yl-6-(tetrahydro-furan-3-yl)-pyrimidin-2-ylamine

Sources & evidence

ORD record
ord-1625cc4388204461b28cc36fad2fc8ce
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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