Toluene → 1-Benzyloxy-7-chloro-6-fluoro-isoquinoline

HRID 807959Notes

Reaction equation

HRID 807959 reaction equation
[Ag+2:33].[Br:14][CH2:15][c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1.[C:29](=[O:30])([O-:31])[O-:32].[CH3:22][c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[Cl:1][c:2]1[c:3]([F:13])[cH:4][c:5]2[cH:6][cH:7][nH:8][c:9](=[O:12])[c:10]2[cH:11]1>>[Cl:1][c:2]1[c:3]([F:13])[cH:4][c:5]2[cH:6][cH:7][n:8][c:9]([O:12][CH2:15][c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[c:10]2[cH:11]1

Participants

6

Reactant 5

HCID 1140TolueneHCID 7498Benzyl BromideHCID 19660Carbonate IonHCID 598182487-Chloro-6-fluoroisoquinolin-1(2H)-oneHCID 178419107HCID 178419107, compound

Product 1

HCID 598182521-Benzyloxy-7-chloro-6-fluoro-isoquinoline

Sources & evidence

ORD record
ord-56dfbeb5bbdd40f1b0dfc4622d0840e9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…