Water → Ethyl 2-(6-amino-5-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)-4-methylpentanoate

HRID 808257Notes

Reaction equation

HRID 808257 reaction equation
[CH3:38][CH2:39][O:40][C:41]([CH3:42])=[O:43].[CH3:45][O:46][CH2:47][CH2:48][O:49][CH3:50].[F:25][C:26]([c:27]1[cH:28][cH:29][c:30]([B:33]([OH:34])[OH:35])[cH:31][cH:32]1)([F:36])[F:37].[NH2:1][c:2]1[c:3]([Br:24])[cH:4][c:5]([CH:14]([C:15](=[O:16])[O:17][CH2:18][CH3:19])[CH2:20][CH:21]([CH3:22])[CH3:23])[cH:6][c:7]1[O:8][CH2:9][C:10]([F:11])([F:12])[F:13].[OH2:44]>>[NH2:1][c:2]1[c:3](-[c:30]2[cH:29][cH:28][c:27]([C:26]([F:25])([F:36])[F:37])[cH:32][cH:31]2)[cH:4][c:5]([CH:14]([C:15](=[O:16])[O:17][CH2:18][CH3:19])[CH2:20][CH:21]([CH3:22])[CH3:23])[cH:6][c:7]1[O:8][CH2:9][C:10]([F:11])([F:12])[F:13]

Participants

6

Reactant 5

HCID 962WaterHCID 80711,2-DimethoxyethaneHCID 8857Ethyl AcetateHCID 27343894-(Trifluoromethyl)phenylboronic acidHCID 57995485Ethyl 2-(4-amino-3-bromo-5-(2,2,2-trifluoroethoxy)phenyl)-4-methylpentanoate

Product 1

HCID 57995476Ethyl 2-(6-amino-5-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)-4-methylpentanoate

Sources & evidence

ORD record
ord-319ef57c5c4a4e81876530032f0005f7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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