Hydrochloric Acid → 6-(3,5-Difluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

HRID 808573Notes

Reaction equation

HRID 808573 reaction equation
[B:38]([Br:39])([Br:40])[Br:41].[CH3:42][OH:43].[Cl:44][CH2:45][Cl:46].[ClH:1].[F:2][c:3]1[cH:4][c:5](-[c:10]2[c:11]([O:22][c:23]3[cH:24][cH:25][c:26]([O:27][CH2:28][CH2:29][N:30]4[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]4)[cH:36][cH:37]3)[c:12]3[cH:13][cH:14][c:15]([O:20][CH3:21])[cH:16][c:17]3[cH:18][cH:19]2)[cH:6][c:7]([F:9])[cH:8]1>>[F:2][c:3]1[cH:4][c:5](-[c:10]2[c:11]([O:22][c:23]3[cH:24][cH:25][c:26]([O:27][CH2:28][CH2:29][N:30]4[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]4)[cH:36][cH:37]3)[c:12]3[cH:13][cH:14][c:15]([OH:20])[cH:16][c:17]3[cH:18][cH:19]2)[cH:6][c:7]([F:9])[cH:8]1

Participants

6

Reactant 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6344DichloromethaneHCID 25134Boron tribromideHCID 575525611-(2-{4-[2-(3,5-Difluoro-phenyl)-6-methoxy-naphthalen-1-yloxy]-phenoxy}-ethyl)-piperidine

Product 1

HCID 670045356-(3,5-Difluoro-phenyl)-5-[4-(2-piperidin-1-yl-ethoxy)-phenoxy]-naphthalen-2-ol

Sources & evidence

ORD record
ord-aa0f91304691479b9aab3540d361a86d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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