Acetate → 2-(4-Methoxy-benzyl)-4,4-dimethyl-7-nitro-3,4-dihydro-2H-isoquinolin-1-one

HRID 808736Notes

Reaction equation

HRID 808736 reaction equation
[Br:1][c:2]1[c:3]([C:4](=[O:5])[N:6]([CH2:7][C:8](=[CH2:9])[CH3:10])[CH2:11][c:12]2[cH:13][cH:14][c:15]([O:18][CH3:19])[cH:16][cH:17]2)[cH:20][c:21]([N+:24](=[O:25])[O-:26])[cH:22][cH:23]1.[C:27]([O-:28])(=[O:29])[CH3:30].[Na+:31].[O:32]=[CH:33][N:34]([CH3:35])[CH3:36]>>[c:2]12[c:3]([cH:20][c:21]([N+:24](=[O:25])[O-:26])[cH:22][cH:23]1)[C:4](=[O:5])[N:6]([CH2:11][c:12]1[cH:13][cH:14][c:15]([O:18][CH3:19])[cH:16][cH:17]1)[CH2:7][C:8]2([CH3:9])[CH3:10]

Participants

5

Reactant 4

HCID 175AcetateHCID 923Sodium ionHCID 6228DimethylformamideHCID 219593762-Bromo-N-(4-methoxy-benzyl)-N-(2-methyl-allyl)-5-nitro-benzamide

Product 1

HCID 219593622-(4-Methoxy-benzyl)-4,4-dimethyl-7-nitro-3,4-dihydro-2H-isoquinolin-1-one

Sources & evidence

ORD record
ord-da1df04677ea417c8ad992ad61e5b6c0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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