Dichloromethane → N-(5-{5-[(2,3-dihydroxypropylamino)sulfonyl]-2-thienyl}-4-methyl-1,3-thiazol-2-yl)acetamide

HRID 808848Notes

Reaction equation

[CH3:1][C:2]1([CH3:27])[O:3][CH2:4][CH:5]([CH2:7][NH:8][S:9](=[O:10])(=[O:11])[c:12]2[cH:13][cH:14][c:15](-[c:17]3[c:18]([CH3:26])[n:19][c:20]([NH:22][C:23]([CH3:24])=[O:25])[s:21]3)[s:16]2)[O:6]1.[Cl:35][CH2:36][Cl:37].[OH:28][C:29]([C:30]([F:31])([F:32])[F:33])=[O:34]>>[OH:3][CH2:4][CH:5]([OH:6])[CH2:7][NH:8][S:9](=[O:10])(=[O:11])[c:12]1[cH:13][cH:14][c:15](-[c:17]2[c:18]([CH3:26])[n:19][c:20]([NH:22][C:23]([CH3:24])=[O:25])[s:21]2)[s:16]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 11998434N-[5-(5-[[(2,2-Dimethyl-1,3-dioxolan-4-YL)methyl]aminosulfonyl}-2-thienyl)-4-methyl-1,3-thiazol-2-YL]acetamide

Product 1

HCID 11998548N-(5-{5-[(2,3-dihydroxypropylamino)sulfonyl]-2-thienyl}-4-methyl-1,3-thiazol-2-yl)acetamide

Sources & evidence

ORD record: ord-a47cafaa6b9e4b598005ae61caeb54fa
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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