Methanol → 4'-Trifluoromethyl-biphenyl-2-carboxylic acid [4-(piperazinyl)-phenyl]-amide

HRID 808876Notes

Reaction equation

HRID 808876 reaction equation
[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH3:41][OH:42].[H:39][H:40].[c:1]1([CH2:2][N:8]2[CH2:9][CH2:10][N:11]([c:14]3[cH:15][cH:16][c:17]([NH:20][C:21](=[O:22])[c:23]4[c:24](-[c:29]5[cH:30][cH:31][c:32]([C:35]([F:36])([F:37])[F:38])[cH:33][cH:34]5)[cH:25][cH:26][cH:27][cH:28]4)[cH:18][cH:19]3)[CH2:12][CH2:13]2)[cH:3][cH:4][cH:5][cH:6][cH:7]1>>[NH:8]1[CH2:9][CH2:10][N:11]([c:14]2[cH:15][cH:16][c:17]([NH:20][C:21](=[O:22])[c:23]3[c:24](-[c:29]4[cH:30][cH:31][c:32]([C:35]([F:36])([F:37])[F:38])[cH:33][cH:34]4)[cH:25][cH:26][cH:27][cH:28]3)[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 22499401N-[4-[4-(phenylmethyl)-1-piperazinyl]phenyl]-4'-(trifluoro-methyl)-[1,1'-biphenyl]-2-carboxamideHCID 178418361HCID 178418361, compound

Product 1

HCID 112010994'-Trifluoromethyl-biphenyl-2-carboxylic acid [4-(piperazinyl)-phenyl]-amide

Sources & evidence

ORD record
ord-040f152df07d46df9417e5c67e8bb836
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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