4-t-Butylbenzenesulfonyl chloride → 8-Iodo-2-(trifluoromethyl)-6-({4-[1-(trifluoromethyl)cyclopropyl]phenyl}sulfonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

HRID 809274Notes

Reaction equation

[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:32]([cH:33]1)[N:18]([S:19]([c:20]1[cH:21][cH:22][c:23]([C:24]([CH3:25])([CH3:26])[CH3:27])[cH:28][cH:29]1)(=[O:30])=[O:31])[CH2:17][c:16]1[c:7]([n:8][c:9]([C:10]([F:11])([F:12])[F:13])[cH:14][cH:15]1)[NH:6]2.[Br:71][c:72]1[cH:73][cH:74][c:75]2[c:89]([cH:90]1)[NH:88][CH2:87][c:86]1[c:77]([n:78][c:79]([C:80]([F:81])([F:82])[F:83])[cH:84][cH:85]1)[NH:76]2.[C:91]([c:92]1[cH:93][cH:94][c:95]([S:96]([Cl:97])(=[O:98])=[O:99])[cH:100][cH:101]1)([CH3:102])([CH3:103])[CH3:104].[F:54][C:55]([C:56]1([c:59]2[cH:60][cH:61][c:62]([S:65](=[O:66])(=[O:67])[Cl:68])[cH:63][cH:64]2)[CH2:57][CH2:58]1)([F:69])[F:70].[I:34][c:35]1[cH:36][cH:37][c:38]2[c:39]([cH:53]1)[NH:40][CH2:41][c:42]1[c:43]([n:45][c:46]([C:49]([F:50])([F:51])[F:52])[cH:47][cH:48]1)[NH:44]2>>[I:34][c:35]1[cH:36][cH:37][c:38]2[c:39]([cH:53]1)[N:40]([S:65]([c:62]1[cH:61][cH:60][c:59]([C:56]3([C:55]([F:54])([F:69])[F:70])[CH2:57][CH2:58]3)[cH:64][cH:63]1)(=[O:66])=[O:67])[CH2:41][c:42]1[c:43]([n:45][c:46]([C:49]([F:50])([F:51])[F:52])[cH:47][cH:48]1)[NH:44]2