1-Methylpiperazine → N-Cyclopropyl-3-fluoro-4-methyl-5-(4-((4-methylpiperazin-1-yl)methyl)-2-(4-(methylsulfonyl)benzyl)-1-oxo-1,2-dihydroisoquinolin-6-yl)benzamide
Reaction equation
[CH3:39][N:40]1[CH2:41][CH2:42][NH:43][CH2:44][CH2:45]1.[CH:1]1([NH:4][C:5]([c:6]2[cH:7][c:8]([F:37])[c:9]([CH3:36])[c:10](-[c:12]3[cH:13][c:14]4[c:15]([CH:34]=[O:35])[cH:16][n:17]([CH2:23][c:24]5[cH:25][cH:26][c:27]([S:30](=[O:31])(=[O:32])[CH3:33])[cH:28][cH:29]5)[c:18](=[O:22])[c:19]4[cH:20][cH:21]3)[cH:11]2)=[O:38])[CH2:2][CH2:3]1>>[CH:1]1([NH:4][C:5]([c:6]2[cH:7][c:8]([F:37])[c:9]([CH3:36])[c:10](-[c:12]3[cH:13][c:14]4[c:15]([CH2:34][N:43]5[CH2:42][CH2:41][N:40]([CH3:39])[CH2:45][CH2:44]5)[cH:16][n:17]([CH2:23][c:24]5[cH:25][cH:26][c:27]([S:30](=[O:31])(=[O:32])[CH3:33])[cH:28][cH:29]5)[c:18](=[O:22])[c:19]4[cH:20][cH:21]3)[cH:11]2)=[O:38])[CH2:2][CH2:3]1Participants
3
Sources & evidence
- ORD record
- ord-e3e76213c56f48b59702b19888392131
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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