反应详情

MeSO2Cl (29 μL) was added to a solution of (S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-3-[(S)-1-(4-piperidin-4-yl-phenyl)-ethyl]-[1,3]oxazinan-2-one (150 mg) and triethylamine (100 μL) in dichloromethane (3 mL) at room temperature. After stirring the solution at room temperature overnight, more dichloromethane was added and the resulting solution was washed with aqueous NaHCO3 solution, water, and brine. The organic solution was then dried (MgSO4) and concentrated. The residue was purified by HPLC on reversed phase (MeCN/H2O/NH3) to afford the title compound.

1. additionwas added
2. washthe resulting solution was washed with aqueous NaHCO3 solution, water, and brine
3. dry with materialThe organic solution was then dried (MgSO4)
4. concentrationconcentrated
5. customThe residue was purified by HPLC on reversed phase (MeCN/H2O/NH3)