Water → Tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate

HRID 809948Notes

Reaction equation

HRID 809948 reaction equation
[C:6]([CH3:7])([CH3:8])([CH3:9])[O:10][C:11](=[O:12])[N:13]1[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]1.[CH2:27]([Cl:28])[Cl:29].[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25].[Cl:1][CH2:2][C:3](=[O:4])[Cl:5].[OH2:26]>>[Cl:1][CH2:2][C:3](=[O:4])[N:16]1[CH2:15][CH2:14][N:13]([C:11]([O:10][C:6]([CH3:7])([CH3:8])[CH3:9])=[O:12])[CH2:18][CH2:17]1

Participants

6

Reactant 5

HCID 962WaterHCID 6344DichloromethaneHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 15829156Tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-3d9193ec8c144b19a2eb440a112f7ef0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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