Bromide ion → 3-Acetyl-1-(3-bromo-2-fluorophenyl)-5-methoxypyridazin-4(1H)-one

HRID 810115Notes

Reaction equation

HRID 810115 reaction equation
[Br-:24].[Br:1][c:2]1[c:3]([F:23])[c:4](-[n:8]2[n:9][c:10]([C:17](=[O:18])[N:19]([O:20][CH3:21])[CH3:22])[c:11](=[O:16])[c:12]([O:14][CH3:15])[cH:13]2)[cH:5][cH:6][cH:7]1.[CH2:27]1[O:28][CH2:29][CH2:30][CH2:31]1.[CH3:25][Mg+:26]>>[Br:1][c:2]1[c:3]([F:23])[c:4](-[n:8]2[n:9][c:10]([C:17](=[O:18])[CH3:25])[c:11](=[O:16])[c:12]([O:14][CH3:15])[cH:13]2)[cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 259Bromide ionHCID 8028TetrahydrofuranHCID 866439361-(3-Bromo-2-fluorophenyl)-N,5-dimethoxy-N-methyl-4-oxo-1,4-dihydropyridazine-3-carboxamideHCID 178477777HCID 178477777, compound

Product 1

HCID 594362583-Acetyl-1-(3-bromo-2-fluorophenyl)-5-methoxypyridazin-4(1H)-one

Sources & evidence

ORD record
ord-1180a9e6d192412fbe0ce5661cd5e1d0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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