反应详情

A mixture of 2,3-dihydro-1H-indole (5.74 g, 48.2 mmol), and (S)-propylene oxide (2.8 g, 48.2 mmol) in ethanol (200 mL) is heated at reflux for 18 hours. The resulting mixture is cooled to room temperature, and evaporated to give a crude oil. The material is purified by flash chromatography (25% ethyl acetate/hexanes) to give 5.37 g (63%) of 2,3-dihydro-1-(2-hydroxypropyl)indole.

1. temperatureis heated
2. temperatureat reflux for 18 hours
3. customevaporated
4. customto give a crude oil
5. customThe material is purified by flash chromatography (25% ethyl acetate/hexanes)