HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Benzoylbenzeneboronic acid → 3-(4-Benzoylphenyl)-5-chloroisonicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Benzoylbenzeneboronic acid | HCID 4197235 | — |
| Reactant | 3,5-Dichloropyridine-4-carbonitrile | HCID 11137599 | — |
| Product | 3-(4-Benzoylphenyl)-5-chloroisonicotinonitrile | HCID 66927492 | 80% |
Reaction Steps
Following conditions described in Step 1 of Example 50, 3,5-dichloroisonicotinonitrile was reacted with 4-benzoylphenylboronic acid to give 3-(4-benzoylphenyl)-5-chloroisonicotinonitrile (˜80% pure). MS (ES+) m/z: 351 (M+H); LC retention time: 3.980 min (analytical HPLC Method A). Step 2:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846673B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-4ec763ac4b0744248fdb65cf47173274 |
| Source note | uspto-grants-2014_09 |