Tetrahydrofuran → Fuzapladib

HRID 810559Notes

Reaction equation

[CH:18]1([C:24](=[O:25])[Cl:26])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1.[NH2:1][c:2]1[c:3]([NH:12][S:13](=[O:14])(=[O:15])[CH2:16][CH3:17])[n:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1.[O:27]1[CH2:28][CH2:29][CH2:30][CH2:31]1>>[NH:1]([c:2]1[c:3]([NH:12][S:13](=[O:14])(=[O:15])[CH2:16][CH3:17])[n:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1)[C:24]([CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1)=[O:25]

Participants

Reactant 3

HCID 8028Tetrahydrofuran

HCID 75938Cyclohexanecarbonyl chloride

HCID 10730665N-(3-amino-5-trifluoromethyl-2-pyridyl)ethanesulfonamide

Product 1

HCID 154529Fuzapladib

Sources & evidence

ORD record: ord-db531712c25e4c0f87fdb97d9b15367e
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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