Acetic Acid → Tert-butyl 4-oxo-octahydropiperazino[2,1-c]morpholine-8-carboxylate

HRID 810569Notes

Reaction equation

HRID 810569 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH2:18][OH:19])[N:11]([C:14]([CH2:15][Cl:16])=[O:17])[CH2:12][CH2:13]1.[C:26]([OH:27])(=[O:28])[CH3:29].[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:20][C:21]([CH3:22])([O-:23])[CH3:24].[K+:25]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]2[N:11]([CH2:12][CH2:13]1)[C:14](=[O:17])[CH2:15][O:19][CH2:18]2

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 813Potassium CationHCID 8028TetrahydrofuranHCID 45749132-Methylpropan-2-olateHCID 66870418Tert-butyl 4-(2-chloroacetyl)-3-(hydroxymethyl)piperazine-1-carboxylate

Product 1

HCID 16123288Tert-butyl 4-oxo-octahydropiperazino[2,1-c]morpholine-8-carboxylate

Sources & evidence

ORD record
ord-90a8840e9eb94c1a950fa53744a99e1a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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