Trifluoroacetic acid → 4-(4-Chloro-2,6-difluoroanilino)-7-hydroxy-6-methoxyquinazoline
Reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([O:29][CH3:30])[cH:11][c:12]2[c:13]([NH:19][c:20]3[c:21]([F:28])[cH:22][c:23]([Cl:27])[cH:24][c:25]3[F:26])[n:14][cH:15][n:16][c:17]2[cH:18]1.[F:31][C:32]([F:33])([F:34])[C:35]([OH:36])=[O:37]>>[OH:8][c:9]1[c:10]([O:29][CH3:30])[cH:11][c:12]2[c:13]([NH:19][c:20]3[c:21]([F:28])[cH:22][c:23]([Cl:27])[cH:24][c:25]3[F:26])[n:14][cH:15][n:16][c:17]2[cH:18]1Participants
3
Sources & evidence
- ORD record
- ord-6a3d2c9396a145e5bdfdc2d967d9e46a
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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