反应详情

To a solution of trans-dimethyl cyclohexane-1,4-dicarboxylate (1000 g, 5 mol) in THF (3000 mL) cooled to −20° C. was added LiAlH4 (570 g, 15 mol). The mixture was stirred at room temperature for 3 h, quenched with water (10 L), and filtered. The filtrate was concentrated in vacuo to give trans-cyclohexane-1,4-diyldimethanol as white solid. 1H NMR (CDCl3, 400 MHz): δ 3.48-3.46 (m, 4H), 1.86-1.84 (m, 4H), 1.47-1.42 (m, 4H), 1.01-0.96 (m, 4H).

1. customquenched with water (10 L)
2. filtrationfiltered
3. concentrationThe filtrate was concentrated in vacuo