Phosphorus oxychloride → 9-Flouro-6-(4-methyl-1-piperazinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

HRID 810950Notes

Reaction equation

HRID 810950 reaction equation
[N:1]1([c:10]2[c:11]([NH:17][C:18](=[O:19])[N:20]3[CH2:21][CH2:22][N:23]([CH3:26])[CH2:24][CH2:25]3)[cH:12][c:13]([F:16])[cH:14][cH:15]2)[CH2:2][CH2:3][c:4]2[cH:5][cH:6][cH:7][cH:8][c:9]21.[P:27]([Cl:28])([Cl:29])([Cl:30])=[O:31]>>[N:1]12[CH2:2][CH2:3][c:4]3[cH:5][cH:6][cH:7][c:8]([c:9]31)[C:18]([N:20]1[CH2:21][CH2:22][N:23]([CH3:26])[CH2:24][CH2:25]1)=[N:17][c:11]1[c:10]2[cH:15][cH:14][c:13]([F:16])[cH:12]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13823350N-[2-(2,3-dihydro-1H-indol-1-yl)-5-fluorophenyl]-4-methyl-1-piperazine carboxamide

Product 1

HCID 138232889-Flouro-6-(4-methyl-1-piperazinyl)-1,2-dihydrobenzo[b]pyrrolo[3,2,1-jk][1,4]benzodiazepine

Sources & evidence

ORD record
ord-e1316b8c87d64a8e9f7d2631f1e6c9aa
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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