Hydrochloric Acid → alpha-(Cyclohexylthio)-alpha-(3,4-dimethoxyphenyl)-3,4-dihydro6,7-dimethoxy-2(1H)-isoquinolineheptane nitrile

HRID 810993Notes

Reaction equation

HRID 810993 reaction equation
[CH3:28][O:29][c:30]1[cH:31][c:32]2[c:37]([cH:38][c:39]1[O:40][CH3:41])[CH2:36][NH:35][CH2:34][CH2:33]2.[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([C:8]#[N:9])([c:10]1[cH:11][c:12]([O:18][CH3:19])[c:13]([O:16][CH3:17])[cH:14][cH:15]1)[S:20][CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1.[ClH:27]>>[CH2:2]([CH2:3][CH2:4][CH2:5][CH2:6][C:7]([C:8]#[N:9])([c:10]1[cH:11][c:12]([O:18][CH3:19])[c:13]([O:16][CH3:17])[cH:14][cH:15]1)[S:20][CH:21]1[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1)[N:35]1[CH2:34][CH2:33][c:32]2[cH:31][c:30]([O:29][CH3:28])[c:39]([O:40][CH3:41])[cH:38][c:37]2[CH2:36]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 156236,7-Dimethoxy-1,2,3,4-TetrahydroisoquinolineHCID 11795020alpha-(5-Chloropentyl)-alpha-(cyclohexylthio)-3,4-dimethoxy-benzeneacetonitrile

Product 1

HCID 10530747alpha-(Cyclohexylthio)-alpha-(3,4-dimethoxyphenyl)-3,4-dihydro6,7-dimethoxy-2(1H)-isoquinolineheptane nitrile

Sources & evidence

ORD record
ord-b27696054faa4c6182d768fbc20563b0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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