2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide

HRID 811022Notes

Reaction equation

HRID 811022 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([CH2:8][N:9]2[CH2:10][CH2:11][P:12]([CH3:15])(=[O:16])[CH2:13][CH2:14]2)[n:7]1.[NH2:17][c:18]1[s:19][c:20](-[c:26]2[c:27]([F:37])[cH:28][c:29]([C:33]([CH3:34])([CH3:35])[OH:36])[cH:30][c:31]2[F:32])[cH:21][c:22]1[C:23](=[O:24])[NH2:25]>>[c:2]1([NH:17][c:18]2[s:19][c:20](-[c:26]3[c:27]([F:37])[cH:28][c:29]([C:33]([CH3:34])([CH3:35])[OH:36])[cH:30][c:31]3[F:32])[cH:21][c:22]2[C:23](=[O:24])[NH2:25])[cH:3][cH:4][cH:5][c:6]([CH2:8][N:9]2[CH2:10][CH2:11][P:12]([CH3:15])(=[O:16])[CH2:13][CH2:14]2)[n:7]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595256551-[(6-Bromopyridin-2-yl)methyl]-4-methyl-1,4-azaphosphinane 4-oxide

Product 1

HCID 595258365-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(4-methyl-4-oxido-1,4-azaphosphinan-1-yl)methyl]pyridin-2-yl}amino)thiophene-3-carboxamide

Sources & evidence

ORD record
ord-cb0d4efb44f049c3ba9ba11e799b3a75
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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