Di-tert-butyl azodicarboxylate → 3-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-4-methyl-benzoic acid ethyl ester

HRID 811177Notes

Reaction equation

HRID 811177 reaction equation
[CH2:28]([CH3:29])[O:30][C:31]([c:32]1[cH:33][c:34]([OH:39])[c:35]([CH3:38])[cH:36][cH:37]1)=[O:40].[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([CH2:14][OH:15])[CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[cH:22][c:23]([F:27])[c:24]([F:26])[cH:25]3)[cH:6][cH:7]1.[N:41]([C:42]([O:43][C:44]([CH3:45])([CH3:46])[CH3:47])=[O:48])=[N:49][C:50]([O:51][C:52]([CH3:53])([CH3:54])[CH3:55])=[O:56]>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[c:11]([n:12]2[CH:13]([CH2:14][O:15][c:34]2[cH:33][c:32]([C:31]([O:30][CH2:28][CH3:29])=[O:40])[cH:37][cH:36][c:35]2[CH3:38])[CH:16]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21]2)[cH:22][c:23]([F:27])[c:24]([F:26])[cH:25]3)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 97268Di-tert-butyl azodicarboxylateHCID 157454893-HYDROXY-4-METHYLBENZOIC ACID ETHYL ESTERHCID 666193102-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethanol

Product 1

HCID 666195213-{2-[2-(4-Chloro-phenyl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-ethoxy}-4-methyl-benzoic acid ethyl ester

Sources & evidence

ORD record
ord-56292e19378b4212862f8bd0604720fc
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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