Bicarbonate Ion → N-[[4-[[cyclopropanecarbonyl(methyl)amino]methyl]pyrrolidin-3-yl]methyl]-4-methoxy-3-(3-methoxypropoxy)-N-propan-2-ylbenzamide

HRID 811486Notes

Reaction equation

HRID 811486 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH:10]([CH2:34][N:35]([CH3:36])[C:37](=[O:38])[CH:39]2[CH2:40][CH2:41]2)[CH:11]([CH2:13][N:14]([C:15]([c:16]2[cH:17][c:18]([O:24][CH2:25][CH2:26][CH2:27][O:28][CH3:29])[c:19]([O:22][CH3:23])[cH:20][cH:21]2)=[O:30])[CH:31]([CH3:32])[CH3:33])[CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[Cl:54][CH2:55][Cl:56].[F:42][C:43]([F:44])([F:45])[C:46]([OH:47])=[O:48].[Na+:53].[O-:49][C:50]([OH:51])=[O:52]>>[NH:8]1[CH2:9][CH:10]([CH2:34][N:35]([CH3:36])[C:37](=[O:38])[CH:39]2[CH2:40][CH2:41]2)[CH:11]([CH2:13][N:14]([C:15]([c:16]2[cH:17][c:18]([O:24][CH2:25][CH2:26][CH2:27][O:28][CH3:29])[c:19]([O:22][CH3:23])[cH:20][cH:21]2)=[O:30])[CH:31]([CH3:32])[CH3:33])[CH2:12]1

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 72311496Tert-butyl 3-[[cyclopropanecarbonyl(methyl)amino]methyl]-4-[[[4-methoxy-3-(3-methoxypropoxy)benzoyl]-propan-2-ylamino]methyl]pyrrolidine-1-carboxylate

Product 1

HCID 68616994N-[[4-[[cyclopropanecarbonyl(methyl)amino]methyl]pyrrolidin-3-yl]methyl]-4-methoxy-3-(3-methoxypropoxy)-N-propan-2-ylbenzamide

Sources & evidence

ORD record
ord-025373aa737c4fcbb39246bfa49b2a0c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…