Acetic Acid → tert-Butyl 4-cyclopropylpiperazine-1-carboxylate

HRID 811636Notes

Reaction equation

HRID 811636 reaction equation
[C:29]([BH3-:30])#[N:31].[CH2:1]([O:2][C:4]1([O:3][Si:7]([CH3:8])([CH3:9])[CH3:10])[CH2:5][CH2:6]1)[CH3:11].[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:12][C:13](=[O:14])[OH:15].[CH3:38][OH:39].[N:16]1([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1.[Na+:32]>>[CH:4]1([N:19]2[CH2:18][CH2:17][N:16]([C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:21][CH2:20]2)[CH2:5][CH2:6]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 887MethanolHCID 923Sodium ionHCID 8028TetrahydrofuranHCID 143452tert-Butyl piperazine-1-carboxylateHCID 498716Cyano-borohydrideHCID 2734686(1-Ethoxycyclopropoxy)trimethylsilane

Product 1

HCID 20294524tert-Butyl 4-cyclopropylpiperazine-1-carboxylate

Sources & evidence

ORD record
ord-17dd4d68da574d9fb2e3ca9eab39f741
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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