Acetic Acid → Methyl 2-(2-aminophenoxy)-5-fluorobenzoate

HRID 811813Notes

Reaction equation

HRID 811813 reaction equation
[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:22][CH2:23][OH:24].[CH3:25][C:26](=[O:27])[OH:28].[F:1][c:2]1[cH:3][cH:4][c:5]([O:12][c:13]2[c:14]([N+:19]([O-:20])=[O:21])[cH:15][cH:16][cH:17][cH:18]2)[c:6]([C:7](=[O:8])[O:9][CH3:10])[cH:11]1.[Pd:34]>>[F:1][c:2]1[cH:3][cH:4][c:5]([O:12][c:13]2[c:14]([NH2:19])[cH:15][cH:16][cH:17][cH:18]2)[c:6]([C:7](=[O:8])[O:9][CH3:10])[cH:11]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 702EthanolHCID 8028TetrahydrofuranHCID 23938PalladiumHCID 59783776Methyl 5-fluoro-2-(2-nitrophenoxy)benzoate

Product 1

HCID 59783706Methyl 2-(2-aminophenoxy)-5-fluorobenzoate

Sources & evidence

ORD record
ord-d4334deaaf424a918b450cf1e05f8b83
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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