Acetonitrile → 1-(2-(3,5-Dimethoxybenzylamino)-4-fluorophenyl)-2,2,2-trifluoroethanone

HRID 811854Notes

Reaction equation

HRID 811854 reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:11][NH2:12])[cH:6][c:7]([O:9][CH3:10])[cH:8]1.[CH3:36][C:37]#[N:38].[CH:27]([N:28]([CH:29]([CH3:30])[CH3:31])[CH2:32][CH3:33])([CH3:34])[CH3:35].[F:13][C:14]([C:15](=[O:16])[c:17]1[c:18]([F:24])[cH:19][c:20]([F:23])[cH:21][cH:22]1)([F:25])[F:26]>>[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:11][NH:12][c:18]2[c:17]([C:15]([C:14]([F:13])([F:25])[F:26])=[O:16])[cH:22][cH:21][c:20]([F:23])[cH:19]2)[cH:6][c:7]([O:9][CH3:10])[cH:8]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 81531DiisopropylethylamineHCID 420973(3,5-Dimethoxyphenyl)methanamineHCID 247268371-(2,4-Difluorophenyl)-2,2,2-trifluoroethanone

Product 1

HCID 587072721-(2-(3,5-Dimethoxybenzylamino)-4-fluorophenyl)-2,2,2-trifluoroethanone

Sources & evidence

ORD record
ord-449c6ce50969481786aefc7c6893a00d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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