Water → ethyl 5-[2-fluoro-4-(2-methoxy-4,6-dimethylpyridin-3-yl)phenyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazole-4-carboxylate

HRID 812101Notes

Reaction equation

[Br:1][c:2]1[c:3]([O:10][CH3:11])[n:4][c:5]([CH3:9])[cH:6][c:7]1[CH3:8].[Br:50][c:51]1[c:52]([CH3:53])[cH:54][c:55]([C:56]#[N:57])[n:58][c:59]1[CH3:60].[C:12](=[O:13])([O-:14])[O-:15].[CH2:61]1[O:62][CH2:63][CH2:64][O:65][CH2:66]1.[Cs+:16].[Cs+:17].[F:18][c:19]1[c:20](-[c:34]2[c:35]([C:45](=[O:46])[O:47][CH2:48][CH3:49])[cH:36][n:37][n:38]2[CH:39]2[CH2:40][CH2:41][O:42][CH2:43][CH2:44]2)[cH:21][cH:22][c:23]([B:25]2[O:26][C:27]([CH3:28])([CH3:29])[C:30]([CH3:31])([CH3:32])[O:33]2)[cH:24]1.[OH2:144].[cH:67]1[cH:68][cH:69][c:70]([P:71]([Pd:72]([P:73]([c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([c:80]2[cH:81][cH:82][cH:83][cH:84][cH:85]2)[c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)([P:92]([c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)([c:99]2[cH:100][cH:101][cH:102][cH:103][cH:104]2)[c:105]2[cH:106][cH:107][cH:108][cH:109][cH:110]2)[P:111]([c:112]2[cH:113][cH:114][cH:115][cH:116][cH:117]2)([c:118]2[cH:119][cH:120][cH:121][cH:122][cH:123]2)[c:124]2[cH:125][cH:126][cH:127][cH:128][cH:129]2)([c:130]2[cH:131][cH:132][cH:133][cH:134][cH:135]2)[c:136]2[cH:137][cH:138][cH:139][cH:140][cH:141]2)[cH:142][cH:143]1>>[c:2]1(-[c:23]2[cH:22][cH:21][c:20](-[c:34]3[c:35]([C:45](=[O:46])[O:47][CH2:48][CH3:49])[cH:36][n:37][n:38]3[CH:39]3[CH2:40][CH2:41][O:42][CH2:43][CH2:44]3)[c:19]([F:18])[cH:24]2)[c:3]([O:10][CH3:11])[n:4][c:5]([CH3:9])[cH:6][c:7]1[CH3:8]