Tetrahydrofuran → Tert-butyl 4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate

HRID 812153Notes

Reaction equation

HRID 812153 reaction equation
[C:19]([Si:20]([CH3:21])([CH3:22])[O:24][CH:25]1[CH2:26][CH:27]([CH2:37][O:38][CH3:39])[N:28]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:29]1)([CH3:23])([CH3:40])[CH3:41].[CH2:2]([N+:3]([CH2:4][CH2:5][CH2:6][CH3:7])([CH2:8][CH2:9][CH2:10][CH3:11])[CH2:12][CH2:13][CH2:14][CH3:15])[CH2:16][CH2:17][CH3:18].[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[F-:1]>>[OH:24][CH:25]1[CH2:26][CH:27]([CH2:37][O:38][CH3:39])[N:28]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[CH2:29]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 19900191Tert-butyl 4-[tert-butyl(dimethyl)silyl]oxy-2-(methoxymethyl)pyrrolidine-1-carboxylate

Product 1

HCID 19900165Tert-butyl 4-hydroxy-2-(methoxymethyl)pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-0f05ef3f37194108888cbde300eebac8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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