Dimethylformamide → Methyl 5-(4-chlorophenyl)nicotinate

HRID 812474Notes

Reaction equation

HRID 812474 reaction equation
[C:12](=[O:13])([O-:14])[O-:15].[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][n:7][cH:8][c:9]([Br:11])[cH:10]1.[CH3:28][N:29]([CH3:30])[CH:31]=[O:32].[Cl:18][c:19]1[cH:20][cH:21][c:22]([B:25]([OH:26])[OH:27])[cH:23][cH:24]1.[Cs+:16].[Cs+:17]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][n:7][cH:8][c:9](-[c:22]2[cH:21][cH:20][c:19]([Cl:18])[cH:24][cH:23]2)[cH:10]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 742994-Chlorophenylboronic acidHCID 104967Cesium cation2×HCID 699336Methyl 5-bromopyridine-3-carboxylate

Product 1

HCID 20099851Methyl 5-(4-chlorophenyl)nicotinate

Sources & evidence

ORD record
ord-af70342c5f8b452d8ef1475751ac22b5
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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