Dichloromethane → 1-Benzylpiperazin-2-one

HRID 812756Notes

Reaction equation

[C:8]([O:9][C:10](=[O:11])[N:15]1[CH2:16][C:17](=[O:28])[N:18]([CH2:21][c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[CH2:19][CH2:20]1)([CH3:12])([CH3:13])[CH3:14].[Cl:29][CH2:30][Cl:31].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[NH:15]1[CH2:16][C:17](=[O:28])[N:18]([CH2:21][c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[CH2:19][CH2:20]1

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 10891590Tert-butyl 4-benzyl-3-oxopiperazine-1-carboxylate

Product 1

HCID 15143031-Benzylpiperazin-2-one

Sources & evidence

ORD record: ord-c4a88f948f9341d5a806aa634fdaa880
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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