Dichloromethane → 4-(3-Pyridazin-3-yl-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

HRID 813062Notes

Reaction equation

[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[c:9]([NH:18][C:19]([CH2:20][C:21](=[O:5])[c:22]2[cH:23][c:24](-[c:28]3[n:29][n:30][cH:31][cH:32][cH:33]3)[cH:25][cH:26][cH:27]2)=[O:35])[cH:10][c:11]([C:14]([F:15])([F:16])[F:17])[cH:12][cH:13]1)([CH3:6])([CH3:34])[CH3:36].[Cl:44][CH2:45][Cl:46].[F:37][C:38]([F:39])([F:40])[C:41]([OH:42])=[O:43]>>[N:7]1=[C:21]([c:22]2[cH:23][c:24](-[c:28]3[n:29][n:30][cH:31][cH:32][cH:33]3)[cH:25][cH:26][cH:27]2)[CH2:20][C:19](=[O:35])[NH:18][c:9]2[c:8]1[cH:13][cH:12][c:11]([C:14]([F:15])([F:16])[F:17])[cH:10]2

Participants

Reactant 3

HCID 6344Dichloromethane

HCID 6422Trifluoroacetic acid

HCID 86589369{2-[3-Oxo-3-(3-pyridazin-3-yl-phenyl)-propionylamino]-4-trifluoromethyl-phenyl}-carbamic acid tert-butyl ester

Product 1

HCID 223174944-(3-Pyridazin-3-yl-phenyl)-8-trifluoromethyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one

Sources & evidence

ORD record: ord-5a30a9d414d4454f8dc854dedf42a330
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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