HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → HCID 58522518, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 7-Methoxy-3,3-dimethylisoindolin-1-one | HCID 10535724 | — |
| Reactant | HCID 131723227 | HCID 131723227 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58522518 | HCID 58522518 | — |
Reaction Steps
7-methoxy-3,3-dimethyl-2,3-dihydro-isoindol-1-one (3.16 g) is dissolved in THF (50 mL) and NaH (7.88 g) is added batchwise. After 5 min methyl iodide (7.18 mL) is added. After 18 h at 0° C. the reaction mixture is combined with H2O/AcCN as well as Isolute and purified by RP HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846689B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-4f5c6075506a48c59f336613d9adedf9 |
| Source note | uspto-grants-2014_09 |