反应详情

温度

0 °C

A solution of 1.2 g of 5-chloro-2-(4-methoxy-3,5-dimethyl-phenyl)-oxazolo[5,4-d]pyrimidine in 42 ml of dichloromethane was cooled to 0° C., and over a period of 10 min 10 ml of a 1 M solution of boron tribromide in dichloromethane was added. The mixture was stirred at 0° C. for 1 h, and then another 3 ml of a 1 M solution of boron tribromide in dichloromethane were added. After stirring for another 1 h, 20 ml of a saturated aqueous solution of sodium hydrogencarboante were added slowly. The precipitate was filtered off and washed with water to give 1 g of the title compound.

1. stirringAfter stirring for another 1 h
2. filtrationThe precipitate was filtered off
3. washwashed with water