Dimethylformamide → tert-Butyl 4-(((3SR,5SR)-3-(2-chloro-4-fluorophenyl)-5-hydroxy-2-oxopiperidin-1-ylimino)(methylthio)methylamino)piperidine-1-carboxylate

HRID 813845Notes

Reaction equation

[Cl:1][c:2]1[c:3]([CH:9]2[C:10](=[O:33])[N:11]([NH:16][C:17]([NH:18][CH:19]3[CH2:20][CH2:21][N:22]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:23][CH2:24]3)=[S:32])[CH2:12][CH:13]([OH:15])[CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[I:34][CH3:35].[O:36]=[CH:37][N:38]([CH3:39])[CH3:40]>>[Cl:1][c:2]1[c:3]([CH:9]2[C:10](=[O:33])[N:11]([N:16]=[C:17]([NH:18][CH:19]3[CH2:20][CH2:21][N:22]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:23][CH2:24]3)[S:32][CH3:35])[CH2:12][CH:13]([OH:15])[CH2:14]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 6328Methyl iodide

HCID 86656717tert-Butyl 4-(3-((3SR,5SR)-3-(2-chloro-4-fluorophenyl)-5-hydroxy-2-oxopiperidin-1-yl)thioureido)piperidine-1-carboxylate

Product 1

HCID 178503960tert-Butyl 4-(((3SR,5SR)-3-(2-chloro-4-fluorophenyl)-5-hydroxy-2-oxopiperidin-1-ylimino)(methylthio)methylamino)piperidine-1-carboxylate

Sources & evidence

ORD record: ord-cbca46a41fac4d158f6fbb5695cb057a
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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