反应详情

27 mg (0.037 mmol) of methyl 4-{[{2-[2-({4-[2-(4-{[tert-butyl(dimethyl)-silyl]oxy}phenyl)ethyl]benzyl}oxy)phenyl]ethyl}(5-ethoxy-5-oxopentyl)amino]-methyl}benzoate from XXI are dissolved in 10 ml of THF. 0.03 ml of tetrabutylammonium fluoride (IM solution in THF) are added, and the solution is stirred at RT for 1 hour. The solvents are evaporated under reduced pressure. The residue is dissolved in 2 ml of methanol. 0.05 ml of aqueous sodium hydroxide solution, 45%, and 0.2 ml of dichloromethane are added, and the solution is stirred at RT for 8 hours. The mixture is concentrated, water is added and the solution is acidified using sulphuric acid. The solid is filtered off and dried.

1. customThe solvents are evaporated under reduced pressure
2. dissolutionThe residue is dissolved in 2 ml of methanol
3. addition0.05 ml of aqueous sodium hydroxide solution, 45%, and 0.2 ml of dichloromethane are added
4. stirringthe solution is stirred at RT for 8 hours
5. concentrationThe mixture is concentrated
6. additionwater is added
7. filtrationThe solid is filtered off
8. customdried