Dichloromethane → 8-(6-Benzyloxy-pyridin-3-yl)-4-(3-trifluoromethyl-phenyl)-1,3-dihydro-benzo[b][1,4]diazepin-2-one
Reaction equation
[C:1]([O:2][C:3](=[O:4])[NH:7][c:8]1[c:9]([NH:28][C:29]([CH2:30][C:31](=[O:5])[c:32]2[cH:33][c:34]([C:38]([F:39])([F:40])[F:41])[cH:35][cH:36][cH:37]2)=[O:43])[cH:10][c:11](-[c:14]2[cH:15][n:16][c:17]([O:20][CH2:21][c:22]3[cH:23][cH:24][cH:25][cH:26][cH:27]3)[cH:18][cH:19]2)[cH:12][cH:13]1)([CH3:6])([CH3:42])[CH3:44].[Cl:52][CH2:53][Cl:54].[F:45][C:46]([F:47])([F:48])[C:49]([OH:50])=[O:51]>>[N:7]1=[C:31]([c:32]2[cH:33][c:34]([C:38]([F:39])([F:40])[F:41])[cH:35][cH:36][cH:37]2)[CH2:30][C:29](=[O:43])[NH:28][c:9]2[c:8]1[cH:13][cH:12][c:11](-[c:14]1[cH:15][n:16][c:17]([O:20][CH2:21][c:22]3[cH:23][cH:24][cH:25][cH:26][cH:27]3)[cH:18][cH:19]1)[cH:10]2Participants
4
Sources & evidence
- ORD record
- ord-f1e4b65c3356469489612477ad205f08
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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