Trifluoroacetic acid → N-[1-(4-Benzo[1,3]dioxol-5-yl-cyclohexyl)-azetidin-3-yl]-2-[1-(2-hydroxy-ethyl)-5-trifluoromethyl-1H-indazol-3-ylamino]-acetamide

HRID 814490Notes

Reaction equation

HRID 814490 reaction equation
[F:26][C:27]([F:28])([F:29])[C:30]([OH:31])=[O:32].[NH:1]1[CH2:2][CH:3]([NH:5][C:6]([CH2:7][NH:8][c:9]2[n:10][n:11]([CH2:22][CH2:23][OH:24])[c:12]3[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][c:17]23)=[O:25])[CH2:4]1.[O:33]1[CH2:34][O:35][c:36]2[c:37]1[cH:38][cH:39][c:40]([CH:42]1[CH2:43][CH2:44][C:45](=[O:48])[CH2:46][CH2:47]1)[cH:41]2>>[N:1]1([CH:45]2[CH2:44][CH2:43][CH:42]([c:40]3[cH:39][cH:38][c:37]4[c:36]([cH:41]3)[O:35][CH2:34][O:33]4)[CH2:47][CH2:46]2)[CH2:2][CH:3]([NH:5][C:6]([CH2:7][NH:8][c:9]2[n:10][n:11]([CH2:22][CH2:23][OH:24])[c:12]3[cH:13][cH:14][c:15]([C:18]([F:19])([F:20])[F:21])[cH:16][c:17]23)=[O:25])[CH2:4]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 10932904AGN-PC-0ND25RHCID 58548860HCID 58548860, compound

Product 1

HCID 54755801N-[1-(4-Benzo[1,3]dioxol-5-yl-cyclohexyl)-azetidin-3-yl]-2-[1-(2-hydroxy-ethyl)-5-trifluoromethyl-1H-indazol-3-ylamino]-acetamide

Sources & evidence

ORD record
ord-e6c848301a9f4e0eb3156c1ff18bc6d9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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