HRID81457

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID1032

未命名化合物

结构：C=CC(=O)Nc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCNC(=O)C1CCCN1C(=O)OC(C)(C)C

HCID90741269

未命名化合物

PRODUCTS

生成物

结构：C=CC(=O)Nc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCCNC(=O)C1CCCN1C(=O)CC

HCID90657049

未命名化合物

收率 83.4%

PROCEDURE

实验过程

The procedure of Example <1-10> was repeated except for using the compound of Example 97 (50 mg, 0.09 mmol) and propionic acid (6.7 mg, 0.09 mmol) to obtain the title compound 45 mg (yield: 82%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c392c7ddd854493d83eb589b0a3c66f2
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08846699B2
来源说明: uspto-grants-2014_09

反应 SMILES

C([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13](=[O:42])[NH:14][CH2:15][CH2:16][O:17][C:18]1[CH:27]=[C:26]2[C:21]([C:22]([NH:28][C:29]3[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][C:30]=3[F:36])=[N:23][CH:24]=[N:25]2)=[CH:20][C:19]=1[NH:37][C:38](=[O:41])[CH:39]=[CH2:40])=O)(C)(C)C.[C:43](O)(=O)[CH2:44]C>>[C:38]([NH:37][C:19]1[CH:20]=[C:21]2[C:26](=[CH:27][C:18]=1[O:17][CH2:16][CH2:15][NH:14][C:13]([CH:9]1[CH2:10][CH2:11][CH2:12][N:8]1[C:6](=[O:5])[CH2:43][CH3:44])=[O:42])[N:25]=[CH:24][N:23]=[C:22]2[NH:28][C:29]1[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][C:30]=1[F:36])(=[O:41])[CH:39]=[CH2:40]