HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propionic Acid → HCID 90657049, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propionic Acid | HCID 1032 | — |
| Reactant | 2-{2-[6-Acryloylamino-4-(4-bromo-2-fluoro-phenylamino)-quinazolin-7-yloxy]-ethylcarbamoyl}-pyrrolidine-1-carboxylic acid t-butylester | HCID 90741269 | — |
| Product | HCID 90657049 | HCID 90657049 | 83.4% |
Reaction Steps
The procedure of Example <1-10> was repeated except for using the compound of Example 97 (50 mg, 0.09 mmol) and propionic acid (6.7 mg, 0.09 mmol) to obtain the title compound 45 mg (yield: 82%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846699B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-c392c7ddd854493d83eb589b0a3c66f2 |
| Source note | uspto-grants-2014_09 |