Acetate → 1-[4-[4-(2,6-Dimethylmorpholin-4-yl)phenyl]piperazin-1-yl]ethanone
Reaction equation
[C:1](=[O:2])([O-:3])[O-:4].[C:61]([CH3:62])(=[O:63])[N:64]1[CH2:65][CH2:66][N:67]([c:70]2[cH:71][cH:72][c:73]([O:76][S:77]([C:78]([F:79])([F:80])[F:81])(=[O:82])=[O:83])[cH:74][cH:75]2)[CH2:68][CH2:69]1.[CH3:53][CH:54]1[O:55][CH:56]([CH3:60])[CH2:57][NH:58][CH2:59]1.[CH3:84][c:85]1[cH:86][cH:87][cH:88][cH:89][cH:90]1.[Cs+:5].[Cs+:6].[O-:92][C:93]([CH3:94])=[O:95].[O-:96][C:97]([CH3:98])=[O:99].[OH2:100].[Pd+2:91].[c:7]1([P:8]([c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[c:15]2[cH:16][cH:17][c:18]3[c:19]([cH:20][cH:21][cH:22][cH:23]3)[c:24]2-[c:25]2[c:26]3[c:27]([cH:28][cH:29][cH:30][cH:31]3)[cH:32][cH:33][c:34]2[P:35]([c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[cH:48][cH:49][cH:50][cH:51][cH:52]1>>[CH3:53][CH:54]1[O:55][CH:56]([CH3:60])[CH2:57][N:58]([c:73]2[cH:72][cH:71][c:70]([N:67]3[CH2:66][CH2:65][N:64]([C:61]([CH3:62])=[O:63])[CH2:69][CH2:68]3)[cH:75][cH:74]2)[CH2:59]1Participants
10
Reactant 9
HCID 175Acetate2×
HCID 962Water
HCID 1140Toluene
HCID 19660Carbonate Ion
HCID 104967Cesium cation2×
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 1108622,6-Dimethylmorpholine
HCID 634876Binap, (A+-)-
HCID 22494772Trifluoromethanesulfonic acid 4-(4-acetylpiperazin-1-yl)phenyl esterProduct 1
Sources & evidence
- ORD record
- ord-265df1ab1e00489f99269decf4619f65
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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