HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → HCID 68180953, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | HCID 86634548 | HCID 86634548 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 68180953 | HCID 68180953 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
A microwave tube is charged with (3-chloro-pyrazin-2-yl)-pyridin-3-yl-methanone (85 mg, 0.39 mmol), DME (2 ml) and 2-methoxyethylamine (0.95 g, 4.26 mmol) and the tube is sealed with a microwave cap. The mixture is heated at 120° C. for 15 hours, then the solvent is removed in vacuo. [3-(2-Methoxy-ethylamino)-pyrazin-2-yl]-pyridin-3-yl-methanone is obtained by flash chromatography (SiO2, toluene/EtOAc, 2:1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846687B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-0c2e91ae72ff45f8aa4309b32dfeb647 |
| Source note | uspto-grants-2014_09 |