2-Methoxyethylamine → HCID 68180953, compound

HRID 81475Notes

Reaction equation

HRID 81475 reaction equation
Cl[C:2]1[C:3]([C:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1.[CH3:16][O:17][CH2:18][CH2:19][NH2:20]>COCCOC>[CH3:16][O:17][CH2:18][CH2:19][NH:20][C:2]1[C:3]([C:8]([C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)=[O:9])=[N:4][CH:5]=[CH:6][N:7]=1

Participants

4

Reactant 2

HCID 80182-MethoxyethylamineHCID 86634548HCID 86634548, compound

Product 1

HCID 68180953HCID 68180953, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
120 °C

Procedure

A microwave tube is charged with (3-chloro-pyrazin-2-yl)-pyridin-3-yl-methanone (85 mg, 0.39 mmol), DME (2 ml) and 2-methoxyethylamine (0.95 g, 4.26 mmol) and the tube is sealed with a microwave cap. The mixture is heated at 120° C. for 15 hours, then the solvent is removed in vacuo. [3-(2-Methoxy-ethylamino)-pyrazin-2-yl]-pyridin-3-yl-methanone is obtained by flash chromatography (SiO2, toluene/EtOAc, 2:1)

Workup

  1. customthe tube is sealed with a microwave
  2. customcap
  3. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-0c2e91ae72ff45f8aa4309b32dfeb647
Source dataset
uspto-grants-2014_09
Patent number
US08846687B2

Reaction notes

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