Hydroxide → 2-(4-Carboxy-2-methoxy-phenylamino)-4-chloro-5-trifluoromethyl-pyrimidine

HRID 814815Notes

Reaction equation

HRID 814815 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[c:11]1[cH:12][c:13]([O:29][CH3:30])[c:14]([NH:17][c:18]2[n:19][cH:20][c:21]([C:25]([F:26])([F:27])[F:28])[c:22]([Cl:24])[n:23]2)[cH:15][cH:16]1.[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[H:31][H:32].[OH-:38].[OH-:40].[Pd+2:39]>>[O:8]=[C:9]([OH:10])[c:11]1[cH:12][c:13]([O:29][CH3:30])[c:14]([NH:17][c:18]2[n:19][cH:20][c:21]([C:25]([F:26])([F:27])[F:28])[c:22]([Cl:24])[n:23]2)[cH:15][cH:16]1

Participants

6

Reactant 5

HCID 961Hydroxide2×HCID 8028TetrahydrofuranHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 582010032-(4-Benzyloxycarbonyl-2-methoxy-phenylamino)-4-chloro-5-trifluoromethyl-pyrimidineHCID 178418361HCID 178418361, compound

Product 1

HCID 589063992-(4-Carboxy-2-methoxy-phenylamino)-4-chloro-5-trifluoromethyl-pyrimidine

Sources & evidence

ORD record
ord-7ba31dd2c0d94165aaa73ffda95b2a97
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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