Bromide ion → Ethyl 3-(4-hydroxypiperidin-1-YL)-3-methylpyrrolidine-1-carboxylate

HRID 814961Notes

Reaction equation

HRID 814961 reaction equation
[Br-:20].[C:1](#[N:2])[C:3]1([N:13]2[CH2:14][CH2:15][CH:16]([OH:19])[CH2:17][CH2:18]2)[CH2:4][N:5]([C:8](=[O:9])[O:10][CH2:11][CH3:12])[CH2:6][CH2:7]1.[CH2:30]1[O:31][CH2:32][CH2:33][CH2:34]1.[CH3:21][Mg+:22].[CH3:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1.[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1>>[CH3:1][C:3]1([N:13]2[CH2:14][CH2:15][CH:16]([OH:19])[CH2:17][CH2:18]2)[CH2:4][N:5]([C:8](=[O:9])[O:10][CH2:11][CH3:12])[CH2:6][CH2:7]1

Participants

6

Reactant 5

HCID 259Bromide ionHCID 1140TolueneHCID 8028Tetrahydrofuran2×HCID 57619828Ethyl 3-cyano-3-(4-hydroxypiperidin-1-YL)pyrrolidine-1-carboxylateHCID 178477777HCID 178477777, compound

Product 1

HCID 57619796Ethyl 3-(4-hydroxypiperidin-1-YL)-3-methylpyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-1dd0009ba1874a7ab846bd7eb48a2704
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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