HCID 54399474, compound → 5(S)Isoxazol-3-ylaminomethyl-3-(4-(2-methylimidazol-1-yl)-3-fluorophenyl)oxazolidin-2-one

HRID 8150Notes

Reaction equation

HRID 8150 reaction equation
[CH3:1][C:2]1[N:3]([C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH2:17][C@H:16]([CH2:18][N:19]([C:27]4[CH:31]=[CH:30][O:29][N:28]=4)C(OC(C)(C)C)=O)[O:15][C:14]3=[O:32])=[CH:9][C:8]=2[F:33])[CH:4]=[CH:5][N:6]=1>ClCCl>[O:29]1[CH:30]=[CH:31][C:27]([NH:19][CH2:18][C@@H:16]2[O:15][C:14](=[O:32])[N:13]([C:10]3[CH:11]=[CH:12][C:7]([N:3]4[CH:4]=[CH:5][N:6]=[C:2]4[CH3:1])=[C:8]([F:33])[CH:9]=3)[CH2:17]2)=[N:28]1

Participants

3

Reactant 1

HCID 54399474HCID 54399474, compound

Product 1

HCID 207257095(S)Isoxazol-3-ylaminomethyl-3-(4-(2-methylimidazol-1-yl)-3-fluorophenyl)oxazolidin-2-oneYield 89.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using essentially the technique of Example 8, but starting from 3-(4-(2-methylimidazol-1-yl)-3-fluorophenyl)-5(R)—(N-(t-butoxycarbonyl)isoxazol-3-ylaminomethyl)oxazolidin-2-one (510 mg, 1.12 mM), and isolating finally by extraction into dichloromethane gave title product (358 mg).

Sources & evidence

ORD record
ord-20a119f7c3384c64958acee5a71e6e1a
Source dataset
uspto-grants-2006_08
Patent number
US07087629B2

Reaction notes

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