Toluene → 4,5-Dimethyl-6-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyridazin-3-yl-acetonitrile

HRID 815253Notes

Reaction equation

[CH3:26][C:27]#[N:28].[CH3:30][Si:31]([N-:32][Si:33]([CH3:34])([CH3:35])[CH3:36])([CH3:37])[CH3:38].[CH3:39][c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1.[Cl:1][c:2]1[n:3][n:4][c:5]([N:10]2[CH2:11][CH2:12][N:13]([c:16]3[n:17][cH:18][c:19]([C:22]([F:23])([F:24])[F:25])[cH:20][cH:21]3)[CH2:14][CH2:15]2)[c:6]([CH3:9])[c:7]1[CH3:8].[Li+:29]>>[c:2]1([CH2:26][C:27]#[N:28])[n:3][n:4][c:5]([N:10]2[CH2:11][CH2:12][N:13]([c:16]3[n:17][cH:18][c:19]([C:22]([F:23])([F:24])[F:25])[cH:20][cH:21]3)[CH2:14][CH2:15]2)[c:6]([CH3:9])[c:7]1[CH3:8]